First, we found that DPG has a wider distribution in group 1 PH (mean DPG was 31.6 mm Hg ± 13.8 mm Hg) than in CPCPH patients. Our analysis of the NIH-PPH database demonstrated two key findings. Relationship Between Diastolic Pulmonary Gradient and Mortality in Patients with "Primary Pulmonary Hypertension" Now Group 1 PH Interestingly, we found that there was an independent association between DPG and 5 year mortality. Therefore, we evaluated the prognostic utility of DPG in patients with "primary pulmonary hypertension", now referred to as group 1 PH, using the National Institute of Health Primary Pulmonary Hypertension (NIH-PPH) database. 2 In these patients, an elevated DPG ≥ 7 mm Hg is associated with increased mortality. 1 Diastolic pulmonary gradient has the appeal of being less sensitive to changes in loading conditions, thereby serving as a robust marker for pre-capillary pulmonary vascular remodeling in patients with pulmonary hypertension- left heart disease (PH-LHD). A DPG value ≥ 7 mm Hg signals the presence of pulmonary vascular remodeling in patients with combined pre- and post-capillary pulmonary hypertension (CPCPH). Respir Med 2016 119:81-6.ĭiastolic pulmonary gradient (DPG) is a novel hemodynamic marker that is calculated as the difference between pulmonary artery diastolic pressure (PADP), and mean pulmonary capillary wedge pressure (PCWP). Diastolic pulmonary gradient predicts outcomes in group 1 pulmonary hypertension (analysis of the NIH primary pulmonary hypertension registry). ![]() ![]() Editor's Note: Expert analysis based on the article Mazimba S, Mejia-Lopez E, Black G, et al.
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